MD6 is the second part of an expansion and modernisation of the National University of Singapore's (NUS) School of Medicine and School of Nursing facilities. MD6, containing both laboratory and teaching spaces, is the centrepiece of the Yong Loo Lin project.

The design expresses the integrated and collaborative nature of teaching and research. The incorporation of engineering requirements and the accommodation of a variety of temporary and long-term site constraints influenced both the internal and exterior form.

Structural design considerations, in particular, have shaped the south side of the project. The concrete structure has been developed to emphasise buildability, and to shape the columns to maximise the utility of the space. MEP equipment is located at basement level, a mid-height mechanical floor and in the rooftop penthouses. Air handling units are divided between 100% fresh outside air for laboratories and re-circulating systems for public spaces. Sustainability analyses have significantly influenced the design of both the exterior envelope and environmental control equipment for the educational and research spaces.