Situated at south of Canteen B, the new 5 to 6-storey School of Physical and Mathematical Sciences is excellently located; its close proximity to the main academic complex allows it to be plugged instantly into the existing network of established schools, research facilities and amenities in the NTU campus.

The new School is planned around a semi-circular open space, the future activities hub, at the southern end of the South Spine. Fanning out from the hub are the buildings of Chemistry, Physics and Mathematics Divisions and shared facilities comprising lecture theatres and tutorial rooms. The three divisions also have an open courtyard and an enclosed atrium in their midst as anchors of the entire building complex.